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KMID : 0368819960350040778
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Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 4 p.778 ~ p.789
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Minor Physical Anomalies, Obsteric Complications and Family Histor of Schizophrenia
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주은정
이중서/홍경수/정희연/신철진/강응구/주연호/김용식
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Abstract
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In order to test the hypothesis that familial schizophrenics have chances of receiving organic insults during the fetal neural development than sporadic schizophrenics, the authors compared obstetric complications, minor anomalies, and other
clinical
features in sibling schizophrenics, sporadic schizophrenics and controls. Obstetric complications were evaluated by the scale of Lewis, and minor physical anomalies were measured by the Waldrop scale.
Sporadic schizophrenics had a significantly higher Waldrop score for mouth than sibling schizophrenics. Although there was some tendency of higher total scores for minor physical anomalies in sporadic schizophrenics there were no statistically
significant differences in obstetric complications and the other minor physical anomalies among three groups. There was no significant correlation between obstetric complication and minor physical anomalies. The clinical features such as age of
onset,
psychopathology, response to drugs, premorbid functioning, and tardive dyskinesia were not significantly different between sibling and sporadic schizophrenics.
In conclusion, while the obstetric complications and minor physical anomalies were suggested to be useful in the search for the cause of schizophrenia, it was difficult to categorize schizophrenics into more homogeneous groups according to family
history of schizophrenia using the parameter of obstetric complications and/or minor physical anomalies.
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